用99锝-二乙三胺五乙酸简化测定肾小球滤过率

A simplified determination of glomerular filtration rate with 99Tcm-DTPA.

作者信息

Galli G, Rufini V, Meduri G

机构信息

Department of Nuclear Medicine, Catholic University of the Sacred Heart, Rome, Italy.

出版信息

Nucl Med Commun. 1994 Oct;15(10):831-5. doi: 10.1097/00006231-199410000-00009.

DOI:10.1097/00006231-199410000-00009

PMID:7838447

Abstract

Using 99Tcm-diethylenetriaminepentaacetate (DTPA) an acceptable estimate of glomerular filtration rate (GFR) can be obtained in adult patients by the equation GF (ml/min) = (0.14 x W + 5) x 1000 x k, where W is the 'ideal' body mass (kg) and k the slope determined by two plasma samples. This has been verified in comparison with the results of the Russell (two samples) and Christensen (one sample) methods in 50 patients. The procedure, which does not require determination of the injected dose, could be useful in patients undergoing sequential renal scintigraphy with 99Tcm-DTPA, for example, to check a doubtful value of glomerular filtration obtained by external counting.

摘要

使用99锝-二乙三胺五乙酸（DTPA），通过公式GF（毫升/分钟）=（0.14×W + 5）×1000×k，可在成年患者中获得可接受的肾小球滤过率（GFR）估计值，其中W是“理想”体重（千克），k是由两个血浆样本确定的斜率。在50例患者中，已将此结果与拉塞尔（两个样本）法和克里斯滕森（一个样本）法的结果进行比较验证。该程序无需测定注射剂量，例如，对于接受99锝-DTPA连续肾闪烁显像的患者，在检查通过外部计数获得的可疑肾小球滤过值时可能有用。