Saito T, Aran J M
Department of Otolaryngology, Fukui Medical School, Japan.
ORL J Otorhinolaryngol Relat Spec. 1994 Nov-Dec;56(6):315-20. doi: 10.1159/000276683.
Functional and morphological alterations were compared in guinea pig cochleae treated acutely (7.5 mg/kg x 2) and chronically (1.5 mg/kg x 10) with cisplatin. Drastic and rapid hearing impairments using compound action potential were observed only after the second injection during acute treatment. During chronic treatment, threshold changes were observed abruptly after 8 or 9 days of treatment. Morphological changes of outer hair cells were stronger in the acute treatment than the chronic one, and they appeared to concur with the functional data. Partial damage in the stria vascularis was observed only after acute treatment. From these results, it was suspected that acute and chronic ototoxic mechanisms differed according to the pharmacokinetics of cisplatin in the inner ear fluid and tissues.
对豚鼠耳蜗进行急性（7.5毫克/千克×2次）和顺铂慢性（1.5毫克/千克×10次）处理后，比较其功能和形态学改变。急性处理时，仅在第二次注射后使用复合动作电位观察到急剧且快速的听力损伤。慢性处理期间，在治疗8或9天后突然观察到阈值变化。急性处理时外毛细胞的形态学改变比慢性处理时更明显，且似乎与功能数据一致。仅在急性处理后观察到血管纹的部分损伤。从这些结果推测，急性和慢性耳毒性机制根据顺铂在内耳液和组织中的药代动力学而有所不同。
