van Lijnschoten G, Arends J W, Geraedts J P
Department of Molecular Cell Biology and Genetics, University of Limburg, Maastricht, The Netherlands.
Placenta. 1994 Oct;15(7):765-73. doi: 10.1016/0143-4004(94)90039-6.
Qualitative and quantitative histological features of a series of induced (n = 6) and spontaneous (n = 24) trisomic abortions were compared. The chorionic villi of induced abortions were large and of irregular contour. The stroma contained many blood vessels and did not show fibrohyalinic change. The intact trophoblast demonstrated 'hyperplasia'. Contrastingly, spontaneous abortions were composed of smaller villi with somewhat more fibrohyalinic stroma containing a few blood vessels. The trophoblast did not show 'hyperplasia'. However, many syncytial knots were present. Although some of histological features were shown to relate to gestational age, which could not be completely matched for, it was unlikely that this could account for the observed differences. Analysis restricted to induced and spontaneous abortions of comparable gestational age demonstrated the same differences. The time-lag between first blood loss and final gestational loss in spontaneous abortions did not appear to be of influence on any of the variables. The striking histopathological differences between induced and spontaneous abortions are mainly considered to be due to cessation of circulation at some time and to disintegration of trophoblast as a result of ischaemia in spontaneous abortions.
对一系列人工流产（n = 6）和自然流产（n = 24）的三体性流产的组织学定性和定量特征进行了比较。人工流产的绒毛膜绒毛大且轮廓不规则。间质中有许多血管，未显示纤维透明样改变。完整的滋养层表现出“增生”。相反，自然流产由较小的绒毛组成，纤维透明样间质稍多，含少量血管。滋养层未显示“增生”。然而，存在许多合体结节。尽管一些组织学特征显示与孕周有关，但无法完全匹配，不太可能是观察到的差异的原因。仅限于可比孕周的人工流产和自然流产的分析显示了相同的差异。自然流产中首次失血与最终妊娠丢失之间的时间间隔似乎对任何变量均无影响。人工流产和自然流产之间显著的组织病理学差异主要被认为是由于自然流产中某一时刻循环停止以及缺血导致滋养层崩解。
