Duyn R J, van Haeringen H
Tijdschr Diergeneeskd. 1995 Jan 15;120(2):46-7.
Hyperkalaemic periodic paralysis is a genetic disease that affects the American Quarter Horse population and is caused by a mutation. As a result of this mutation in a gene which codes for the sodium channel in muscle cells, severe muscle weakness can appear. Reliable DNA-tests can establish whether a horse is homozygous negative, heterozygous, or homozygous positive for this mutation. Therapy and prevention are discussed.
高钾性周期性麻痹是一种影响美国夸特马种群的遗传性疾病,由基因突变引起。由于肌肉细胞中编码钠通道的基因发生这种突变,可能会出现严重的肌肉无力。可靠的DNA检测可以确定一匹马对于这种突变是纯合阴性、杂合还是纯合阳性。文中还讨论了治疗和预防方法。