Ohshima S, Yagi T, Funahashi Y
Department of Mechanical Engineering, Nagoya Institute of Technology, Japan.
Vision Res. 1995 Jan;35(1):149-60. doi: 10.1016/0042-6989(94)e0043-k.
We propose an equivalent circuit model of a discrete formulation to describe the interaction between the red cone syncytium and the H1 horizontal cell syncytium in lower vertebrate retinas. Analytical solutions of the model provide intuitive understandings of spatio-temporal properties of light-induced responses in reference to membrane impedance, strength of chemical synapse and coupling resistance connecting neighbouring cells. Physiologically plausible values of these parameters are estimated using the solutions. Quantitative studies are made to elucidate the function of (1) the negative feedback from the H1 horizontal cell to the red cone, and (2) the resistance increase of H1 horizontal cell coupling by dopamine.
我们提出了一种离散形式的等效电路模型，以描述低等脊椎动物视网膜中红色视锥细胞合体与H1水平细胞合体之间的相互作用。该模型的解析解提供了关于光诱导反应时空特性的直观理解，涉及膜阻抗、化学突触强度以及连接相邻细胞的耦合电阻。利用这些解估计了这些参数的生理合理值。进行了定量研究，以阐明（1）H1水平细胞对红色视锥细胞的负反馈，以及（2）多巴胺对H1水平细胞耦合电阻增加的作用。
