[胱胺对辐照后单链DNA断裂形成及修复的影响]
[Effect of cystamine on formation and repair of post-irradiation single-strand DNA breaks].
作者信息
Vladimirov V G, Lebedev S N, Antushevich A E
出版信息
Vopr Med Khim. 1994 Sep-Oct;40(5):27-30.
PMID:7839665
Abstract
Content of breaks in single-strand DNA, activity of superoxide dismutase and concentration of malonic dialdehyde were studied in blood lymphocytes of irradiation-impaired rats after treatment with cystamine. Cystamine decreased the effects of irradiation as showed all the patterns studied. The protective action exhibited by the drug in radiation shielding of DNA involved both direct and indirect effects.
摘要
研究了用半胱胺处理后的辐射损伤大鼠血液淋巴细胞中单链DNA断裂的含量、超氧化物歧化酶的活性和丙二醛的浓度。半胱胺减轻了辐射的影响，在所研究的所有指标上均有体现。该药物在DNA辐射防护中表现出的保护作用涉及直接和间接效应。
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