Uchihara T, Mitani K, Mori H, Kondo H, Yamada M, Ikeda K
Department of Neurology, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Acta Neuropathol. 1994;88(4):379-83. doi: 10.1007/BF00310383.
An autopsy case of clinically diagnosed "corticobasal degeneration (CBD)" was investigated. In addition to status spongiosus and neuronal achormasia around the central sulcus, cortical pyramidal neurons and thread-like structures were densely stained by Gallyas stain and tau immunohistochemistry, but apparent fibrillary structures like Alzheimer's disease neurofibrillary tangle were absent. Bodian, methenamine-Bodian, Congo red, thioflavin S, or Bielshowsky stains failed to visualize these structures. They were not stained by immunohistochemical stain with anti-ubiquitin antibody. The widespread cytoskeletal pathology, which is distinct from that in Alzheimer's disease or progressive supranuclear palsy, is suggestive of CBD.
对一例临床诊断为“皮质基底节变性（CBD）”的尸检病例进行了研究。除中央沟周围海绵状状态和神经元色素脱失外，皮质锥体细胞和丝状结构经加利亚斯染色和tau免疫组化呈密集染色，但未发现像阿尔茨海默病神经原纤维缠结那样明显的纤维状结构。博迪安染色、亚甲胺银-博迪安染色、刚果红染色、硫黄素S染色或 Bielshowsky染色均未能使这些结构显影。它们未被抗泛素抗体免疫组化染色所染。这种广泛的细胞骨架病理改变不同于阿尔茨海默病或进行性核上性麻痹，提示为CBD。
