Oyediran A B, Topley E, Osunkoya B O, Bamgboye A, Williams A I, Ogunba E O, Asuzu M C
Department of Preventive and Social Medicine, University of Ibadan, Nigeria.
Afr J Med Med Sci. 1993 Mar;22(1):55-63.
In a controlled trial of weekly malaria chemoprophylaxis with chloroquine and pyrimethamine there were no significant differences in type and frequency of severe morbidity during chemoprophylaxis. Administration of chemoprophylaxis during the current and immediately preceding month was associated with significantly fewer episodes of severe morbidity in the chloroquine and pyrimethamine groups when each was compared with the control multivite group. After chemoprophylaxis had been stopped, significantly more episodes of severe morbidity occurred in the chloroquine group than the control group, but a similar trend in the pyrimethamine group was not statistically significant. In the control group most of the episodes of severe morbidity, including those episodes which were associated with heavy parasitaemia, occurred below the age of 4 years. In contrast, the children who received chemoprophylaxis continued to experience such illness at older ages. The difference between the chloroquine group and the control group in respect of age at time of severe morbidity was statistically significant.
在一项关于氯喹和乙胺嘧啶每周疟疾化学预防的对照试验中，化学预防期间严重发病的类型和频率没有显著差异。与对照多种维生素组相比，在当月和紧接前一个月进行化学预防时，氯喹组和乙胺嘧啶组的严重发病次数显著减少。化学预防停止后，氯喹组的严重发病次数显著多于对照组，但乙胺嘧啶组的类似趋势无统计学意义。在对照组中，大多数严重发病情况，包括那些与高寄生虫血症相关的情况，发生在4岁以下。相比之下，接受化学预防的儿童在较大年龄时仍会出现此类疾病。氯喹组和对照组在严重发病时的年龄差异具有统计学意义。
