Ojogwu L I, Ukoli F A
Department of Medicine, University of Benin Teaching Hospital, Nigeria.
Afr J Med Med Sci. 1993 Jun;22(2):43-50.
Clinical data from 88 patients who presented with the nephrotic syndrome and biopsy proven glomerular disease were analysed to determine the outcome after 8 years of follow up, and to find out the influence of glomerular histology, sex, age, plasma creatinine, creatinine clearance, hypertension, 24-hour urinary protein excretion and microscopic haematuria, on the clinical course and outcome. The results showed that at the end of follow up (8 years), 13 patients (14.8%) had died from renal failure while 24 patients (27.2%) were in chronic renal failure. Persistent renal disease was still present in 29 patients (33.0%). Of the whole group (88), mortality and endstage renal failure were highest amongst patients with focal segmental glomerulosclerosis and membrano-proliferative glomerulonephritis. Male sex, hypertension, impaired plasma creatinine and creatinine clearance in patients from these two groups were associated with progression to chronic renal failure and death from uraemia. At final observation hypertension and microscopic haematuria were marked features of these two histological groups. Prognosis in minimal change nephropathy was quite good with remission occurring in 20 patients (66.6%); persistent renal disease however occurred in 8 patients (26.6%) while 1 patient died from uraemia.
对88例表现为肾病综合征且经活检证实患有肾小球疾病的患者的临床数据进行分析，以确定8年随访后的结果，并了解肾小球组织学、性别、年龄、血浆肌酐、肌酐清除率、高血压、24小时尿蛋白排泄量和镜下血尿对临床病程及结果的影响。结果显示，在随访结束时（8年），13例患者（14.8%）死于肾衰竭，24例患者（27.2%）处于慢性肾衰竭状态。29例患者（33.0%）仍存在持续性肾脏疾病。在整个研究组（88例）中，局灶节段性肾小球硬化症和膜增生性肾小球肾炎患者的死亡率和终末期肾衰竭发生率最高。这两组患者中的男性、高血压、血浆肌酐和肌酐清除率受损与进展为慢性肾衰竭及死于尿毒症相关。在最终观察中，高血压和镜下血尿是这两种组织学类型患者的显著特征。微小病变肾病的预后相当好，20例患者（66.6%）实现缓解；然而，8例患者（26.6%）出现持续性肾脏疾病，1例患者死于尿毒症。
