Gorwood P, Leboyer M, Jay M, Payan C, Feingold J
Laboratoire d'épidémiologie génétique (Institut National de la Santé et de la Recherche Médicale Unité 155), Université de Paris VII, France.
Am J Psychiatry. 1995 Feb;152(2):208-12. doi: 10.1176/ajp.152.2.208.
The 1-year prevalence of schizophrenia was studied in a limited geographical area of Reunion Island (Indian Ocean) to assess the impact of family history of schizophrenia on the well-known association between gender and age at onset.
The population of schizophrenic patients meeting the DSM-III-R criteria for schizophrenia (N = 663) was identified and divided according to the presence of another schizophrenic patient among the first- and second-degree relatives.
As previously reported, the median age at onset differed between the sexes: the males had an earlier onset (mean age = 27.8 years) than the females (31.5 years). Comparison of the ages at onset according to family history revealed that onset was later for female subjects with a negative family history than for the three other groups (i.e., males with or without a family history and females with a family history). No difference emerged in the comparison of the ages at onset of the males and females with a positive family history.
Comparison of schizophrenic patients with familial versus sporadic disorder confirms the absence of a gender effect for age at onset in the subgroup with familial disorder. This approach also demonstrates the existence of a subgroup composed of affected females having late onset and no family history of schizophrenia.
在留尼汪岛（印度洋）的一个有限地理区域内研究精神分裂症的1年患病率，以评估精神分裂症家族史对性别与发病年龄之间著名关联的影响。
确定符合精神分裂症DSM-III-R标准的精神分裂症患者群体（N = 663），并根据一级和二级亲属中是否存在另一名精神分裂症患者进行划分。
如先前报道，发病年龄中位数在性别之间存在差异：男性发病较早（平均年龄 = 27.8岁），女性为（31.5岁）。根据家族史对发病年龄进行比较，结果显示家族史阴性的女性受试者发病年龄比其他三组（即有或无家族史的男性以及有家族史的女性）晚。有家族史的男性和女性在发病年龄比较上未出现差异。
对家族性与散发性精神分裂症患者的比较证实，在家族性疾病亚组中发病年龄不存在性别效应。这种方法还证明存在一个由发病较晚且无精神分裂症家族史的受影响女性组成的亚组。
