Elbaz D
ORL, Paris.
Ann Otolaryngol Chir Cervicofac. 1994;111(3):141-4.
Through this analysis we shall report our experience about botulinum toxin in view of relieving blepharospasm and hemifacial spasm. Many Treatments have been tested with very inconstant often deceptive and sometimes even dangerous results. The present method gives us the possibility to paralyze the spasmed muscles by direct injection into the muscle. After 58 ambulatory injections, 53 effective results were obtained with complete spasm relief for a mean internal of 4 to 5 months. No systemic effect was noticed, but some transient ophthalmic incidents occurred: they can be avoided by simple technical precautions. In hemifacial spasm, the orbicularis eyelid muscle seems to be the "spasm starter" and its unique injection by toxin can often relieve the whole hemiface. This simple method appears remarkably effective, although its duration is limited to a few months; but the injections can be conveniently repeated. However, this technique has to be carefully performed by experienced physicians. It is extremely regrettable to see the enormous price increase of toxin within the last years. This limits a larger use for patients good health.
通过本次分析，我们将汇报我们在使用肉毒杆菌毒素缓解眼睑痉挛和半面痉挛方面的经验。许多治疗方法都经过了测试，但结果常常不稳定，具有欺骗性，有时甚至很危险。目前的方法使我们能够通过直接向肌肉注射来麻痹痉挛的肌肉。在进行了58次门诊注射后，53例取得了有效结果，痉挛完全缓解，平均持续时间为4至5个月。未观察到全身效应，但出现了一些短暂的眼部问题：通过简单的技术预防措施可以避免这些问题。在半面痉挛中，眼轮匝肌似乎是“痉挛起始者”，仅对其注射毒素往往就能缓解整个半侧面部的痉挛。这种简单的方法似乎非常有效，尽管其持续时间仅限于几个月；但注射可以方便地重复进行。然而，这项技术必须由经验丰富的医生谨慎操作。看到毒素在过去几年中价格大幅上涨，令人极为遗憾。这限制了其在更多患者健康方面的广泛应用。
