Wiesel F A, Venizelos N, Bjerkenstedt L, Hagenfeldt L
Department of Psychiatry, Uppsala University, Sweden.
Schizophr Res. 1994 Oct;13(3):255-8. doi: 10.1016/0920-9964(94)90050-7.
Tyrosine transport was examined in cultured skin fibroblasts from patients with schizophrenia (DSM-III-R) and normal subjects. The transport capacity (Vmax) was lower in the patients. The results confirm previous findings of decreased tyrosine transport in schizophrenia. In cells incubated with psychotropic drugs at different concentrations, tyrosine transport was not differentially influenced across patients and normal subjects. Dopaminergic and beta-adrenergic receptor mechanisms did not seem to influence tyrosine uptake. There seems to be a primary disturbance of tyrosine transport in schizophrenia which indicates a generalized cell membrane dysfunction.
对精神分裂症患者（DSM-III-R）和正常受试者的培养皮肤成纤维细胞中的酪氨酸转运进行了检测。患者的转运能力（Vmax）较低。这些结果证实了先前关于精神分裂症中酪氨酸转运减少的发现。在用不同浓度的精神药物孵育的细胞中，患者和正常受试者的酪氨酸转运没有受到不同的影响。多巴胺能和β-肾上腺素能受体机制似乎不影响酪氨酸摄取。精神分裂症中似乎存在酪氨酸转运的原发性障碍，这表明存在普遍的细胞膜功能障碍。
