Hagenfeldt L, Venizelos N, Bjerkenstedt L, Wiesel F A
Department of Clinical Chemistry, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
Life Sci. 1987 Dec 21;41(25):2749-57. doi: 10.1016/0024-3205(87)90468-1.
Amino acid transport was studied in vitro in cultured fibroblasts from schizophrenic patients and controls. An isolated decrease in the transport capacity (Vmax) for tyrosine was observed in cells from the patients. The Km for tyrosine transport was unaffected. The kinetic parameters for phenylalanine, tryptophan, leucine and glycine transport did not differ between patients and controls. Competitive inhibition among the amino acids transported by the L-system and its exchange properties were normal in cells from the patients. No differences in intracellular levels of amino acids between patients and controls were observed. The decreased tyrosine transport in the cells from schizophrenic patients appears not to be related to any known amino acid transport system and may reflect a more general defect in plasma membrane function in schizophrenia.
对精神分裂症患者和对照组的培养成纤维细胞进行了体外氨基酸转运研究。在患者细胞中观察到酪氨酸转运能力（Vmax）单独降低。酪氨酸转运的Km未受影响。患者和对照组之间苯丙氨酸、色氨酸、亮氨酸和甘氨酸转运的动力学参数没有差异。患者细胞中由L-系统转运的氨基酸之间的竞争性抑制及其交换特性正常。未观察到患者和对照组之间细胞内氨基酸水平的差异。精神分裂症患者细胞中酪氨酸转运减少似乎与任何已知的氨基酸转运系统无关，可能反映了精神分裂症中质膜功能更普遍的缺陷。
