赖氨酸与雌酮3,4 - o - 醌的反应。

Reaction of lysine with estrone 3,4-o-quinone.

作者信息

Tabakovic K, Abul-Hajj Y J

机构信息

Department of Medicinal Chemistry, University of Minnesota, Minneapolis 55455.

出版信息

Chem Res Toxicol. 1994 Sep-Oct;7(5):696-701. doi: 10.1021/tx00041a016.

DOI:10.1021/tx00041a016

PMID:7841350

Abstract

Reaction of lysine with estrone 3,4-o-quinone gave a complex mixture of products. Six compounds were isolated and identified using spectroscopic techniques. Among the reaction products isolated were 4-hydroxyestrone (2), 3-aminoisoestrone (3), 3-(N-pentyl-5-amino)-isoestrone (4), 1-lysylestrone 3,4-o-iminoquinone (5), and two dimeric products of 3,4-catechol estrone (6 and 7).

摘要

赖氨酸与雌酮3,4 - o -醌反应生成了复杂的产物混合物。使用光谱技术分离并鉴定了六种化合物。分离出的反应产物包括4 - 羟基雌酮（2）、3 - 氨基异雌酮（3）、3 -（N - 戊基 - 5 - 氨基）- 异雌酮（4）、1 - 赖氨酰雌酮3,4 - o - 亚氨基醌（5）以及3,4 - 儿茶酚雌酮的两种二聚体产物（6和7）。