Bourlond A
Department of Dermatology, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium.
Dermatology. 1994;189 Suppl 2:46-9. doi: 10.1159/000246990.
Mammary and extramammary Paget's disease is believed to remain non-pigmented, in contrast to superficial pagetoid melanoma; the same holds true for epidermotropic metastases of breast carcinoma. We recently had the opportunity to observe intensively pigmented epidermotropic metastasis of breast carcinoma, with dispersion of melanocytes in the dermal infiltrate. Similar observations, although exceedingly rare, have been reported: melanocytes 'may' pullulate within the dermo-epidermal foci of malignant epithelial cells. The final diagnosis relies on very careful analysis and, as far as possible, on immunohistological techniques.
与浅表性派杰样黑色素瘤不同，乳腺和乳腺外佩吉特病被认为是无色素沉着的；乳腺癌的亲表皮转移也同样如此。我们最近有机会仔细观察了一例色素沉着明显的乳腺癌亲表皮转移病例，真皮浸润中有黑素细胞散在分布。尽管极为罕见，但已有类似观察结果的报道：黑素细胞“可能”在恶性上皮细胞的真皮表皮病灶内大量增殖。最终诊断依赖于非常仔细的分析，并且尽可能采用免疫组织学技术。
