[脂质体与阿霉素偶联的抗卵巢癌单克隆抗体靶向治疗]

[Target therapy by monoclonal antibody against ovarian carcinoma conjugated with liposomes and adriamycin].

作者信息

Li W J, Qian H N, Lu W Y

机构信息

Department of Obstetrics and Gynecology, Affiliated People's Hospital, Beijing Medical University.

出版信息

Zhonghua Yi Xue Za Zhi. 1994 Sep;74(9):539-41, 582.

Abstract

Conjugates of monoclonal antibody COC166-9 and adriamycin entrapped in liposome (MLA) were prepared in our laboratory. In vitro growth inhibition of SKOV3 ovarian carcinoma cell line was carried out by MLA and controls. Target therapies by MLA, adriamycin, normal mouse IgG instead of MAb, and control were given for 24 nude mice models with subcutaneous human ovarian carcinoma xenografts and 16 ascitic ovarian carcinoma respectively. MLA group showed the best therapeutic effect than all the other groups which gave a helpful clue to clinical use.

摘要

我们实验室制备了脂质体包裹的单克隆抗体COC166-9与阿霉素的偶联物（MLA）。通过MLA和对照对SKOV3卵巢癌细胞系进行体外生长抑制实验。分别对24只皮下接种人卵巢癌异种移植物的裸鼠模型和16只卵巢癌腹水模型给予MLA、阿霉素、用正常小鼠IgG代替单克隆抗体以及对照进行靶向治疗。MLA组显示出比所有其他组更好的治疗效果，这为临床应用提供了有益线索。

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