Slavc I, Salchegger C, Hauer C, Urban C, Oberbauer R, Pakisch B, Ebner F, Schwinger W, Mokry M, Ranner G
Department of Pediatrics, University of Graz, Austria.
Childs Nerv Syst. 1994 Sep;10(7):433-43. doi: 10.1007/BF00303608.
We report the findings at follow-up in 67 consecutive children with central nervous system tumors treated over a 5-year-period at a single institution. The diagnoses were supratentorial astrocytoma (n = 12), cerebellar astrocytoma (n = 10), ependymoma (n = 9), medulloblastoma (n = 9), brain stem glioma (n = 6), optic pathway glioma (n = 5), and others (n = 16). The survival rates were 83% for supratentorial astrocytomas at a median of 46.5 months, 90% for cerebellar astrocytomas and 55% for ependymomas at 40 months, respectively, 55% for medulloblastomas at 22 months, 33% for brain stem gliomas at 23 months, and 80% for optic pathway gliomas at 49 months. With regard to neurological sequelae, 13 patients were treated for epilepsy, 13 patients had mild to moderate neurological deficits, and 4 patients were severely disabled. Seventeen of 37 tested patients performed below average on formal neuropsychometric testing, one-fourth attended special education courses, and at least one-fourth suffered from behavioral and adjustment problems.
我们报告了在一家机构连续5年治疗的67例中枢神经系统肿瘤患儿的随访结果。诊断包括幕上星形细胞瘤（n = 12）、小脑星形细胞瘤（n = 10）、室管膜瘤（n = 9）、髓母细胞瘤（n = 9）、脑干胶质瘤（n = 6）、视神经通路胶质瘤（n = 5）以及其他类型（n = 16）。幕上星形细胞瘤的生存率在46.5个月时为83%，小脑星形细胞瘤在40个月时为90%，室管膜瘤在40个月时为55%，髓母细胞瘤在22个月时为55%，脑干胶质瘤在23个月时为33%，视神经通路胶质瘤在49个月时为80%。关于神经后遗症，13例患者接受了癫痫治疗，13例患者有轻度至中度神经功能缺损，4例患者严重残疾。在37例接受测试的患者中，17例在正式神经心理测试中的表现低于平均水平，四分之一的患者参加了特殊教育课程，至少四分之一的患者存在行为和适应问题。
