Rosen G D, Sherman G F, Galaburda A M
Dyslexia Research Laboratory, Beth Israel Hospital, Boston, MA 02215.
Brain Res Dev Brain Res. 1994 Oct 14;82(1-2):127-35. doi: 10.1016/0165-3806(94)90155-4.
Microgyria can be induced in otherwise normal rat neocortex by a freezing injury to the cortical plate before the completion of neuronal migration. We had previously reported radial glial like-immunoreactive fibers in the area of the microgyria in 32-day-old rats. Here we demonstrate that these glial fibers, which are immunoreactive to Rat-401, vimentin, and glial fibrillary acidic protein (GFAP) antibodies, are seen in adult rats. The appearance of these fibers is hypothesized to result from the release of a trophic factor during the recovery from neonatal injury which acts to either (1) halt the transformation of radial glia to astrocytes and/or dedifferentiate already committed astrocytes, (2) create a hybrid cell, or (3) induce increased proliferation of glia.
在神经元迁移完成之前，通过对皮质板进行冷冻损伤，可在原本正常的大鼠新皮质中诱发微小脑回。我们之前报道过，在32日龄大鼠微小脑回区域存在放射状胶质样免疫反应性纤维。在此我们证明，这些对大鼠401、波形蛋白和胶质纤维酸性蛋白（GFAP）抗体具有免疫反应性的胶质纤维，在成年大鼠中也可见。据推测，这些纤维的出现是由于新生损伤恢复过程中一种营养因子的释放，该因子的作用可能是：（1）阻止放射状胶质细胞向星形胶质细胞的转化和/或使已经分化的星形胶质细胞去分化；（2）产生一种杂交细胞；或（3）诱导胶质细胞增殖增加。
