Hong D Q, Li J S, Dai H M
Department of Epidemiology Nanjing Medical University.
Zhonghua Yu Fang Yi Xue Za Zhi. 1994 Sep;28(5):287-90.
One hundred and three HBsAg carriers were followed up for 16-21 years with an average of 18.6 years. Results showed 30 of them recovered from carrier status. 26 became post-hepatitis carriers and 21 asymptomatic carriers, six suffered from acute hepatitis B and seven chronic active hepatitis, and 13 died. Negative conversion rate of HBsAg averaged 33.3% with 13.8% for those aged 30 or less and 42.6% for those over 30. Negative conversion rate of HBsAg and recover rate in carriers with high-titer HBsAg were very significantly lower, and incidence rates of acute hepatitis B and chronic active hepatitis significantly higher than those with low titer.
103名乙肝表面抗原（HBsAg）携带者接受了16至21年的随访，平均随访时间为18.6年。结果显示，其中30人从携带者状态康复。26人成为肝炎后携带者，21人成为无症状携带者，6人患急性乙型肝炎，7人患慢性活动性肝炎，13人死亡。HBsAg转阴率平均为33.3%，30岁及以下者为13.8%，30岁以上者为42.6%。高滴度HBsAg携带者的HBsAg转阴率和康复率非常显著地低于低滴度携带者，急性乙型肝炎和慢性活动性肝炎的发病率则显著高于低滴度携带者。
