Hong X R, Li M, Cao J Z
Changhai Hospital, Second Military Medical College, Shanghai.
Zhonghua Wai Ke Za Zhi. 1994 Apr;32(4):220-3.
Dynamic changes of contents of beta-endorphin, leu-enkephalin and oxytocin in plasma were determined in seventeen fracture patients with shock, fascial space syndromes, or infection postoperation. There was significant rise of contents in beta-endorphin and leu-enkephalin but not in oxytocin after trauma, Of those accompanied by infection postoperation, beta-endorphin and oxytocin remained high. The contents of beta-endorphin and enkephalin decreased gradually in non-infectious group, but were still higher than normal. The most obvious change was seen in beta-endorphin, suggesting that beta-endorphin plays a more important role in trauma. This was also confirmed in rat injury model.
对17例伴有休克、筋膜间隙综合征或术后感染的骨折患者血浆中β-内啡肽、亮氨酸脑啡肽和催产素含量的动态变化进行了测定。创伤后β-内啡肽和亮氨酸脑啡肽含量显著升高，但催产素含量未升高。在伴有术后感染的患者中，β-内啡肽和催产素仍维持在较高水平。非感染组中β-内啡肽和脑啡肽含量逐渐下降，但仍高于正常水平。β-内啡肽的变化最为明显，表明β-内啡肽在创伤中发挥着更重要的作用。这在大鼠损伤模型中也得到了证实。
