Wang S, Yu Y X, Zhang J Q
People's Hospital, Beijing Medical University.
Zhonghua Wai Ke Za Zhi. 1994 May;32(5):289-91.
A multivariate stepwise discriminant analysis was performed to evaluate the prognostic value of DI, PI, AgNOR, p21D, CEAD and several clinicopathological features (age, sex, tumor location, histological grading, typing and staging) in 83 patients with colorectal cancer who underwent radical surgery. A fisher's discriminant function was established by using 6 selected items (staging, grading, DI, PI, AgNOR and p21D). It's efficiency, sensitivity and specificity were 91.28%, 87.18%, and 95.45% respectively. Correlative studies on DI, PI, AgNOR and p21D indicated that they are independent factors influencing prognosis. Therefore, in addition to Dukes's classification and histopathological grading of the tumor, these molecular biological factors can be considered as a new clue to evaluation of patients prognosis.
对83例行根治性手术的结直肠癌患者，进行多因素逐步判别分析，以评估DI、PI、AgNOR、p21D、CEAD及若干临床病理特征（年龄、性别、肿瘤部位、组织学分级、分型及分期）的预后价值。采用6项入选指标（分期、分级、DI、PI、AgNOR和p21D）建立了Fisher判别函数。其效率、敏感性和特异性分别为91.28%、87.18%和95.45%。对DI、PI、AgNOR和p21D的相关性研究表明，它们是影响预后的独立因素。因此，除了肿瘤的Dukes分期和组织病理学分级外，这些分子生物学因素可被视为评估患者预后的新线索。
