Guo X Y, Ye T H, Luo A L
Peking Union Medical College Hospital, Beijing.
Zhonghua Wai Ke Za Zhi. 1994 Jul;32(7):435-7.
The efficacy and safety of prophylactic intravenous ondansetron on prevention of postoperative nausea and vomiting were investigated in 65 ASA grades I-III patients undergoing elective abdominal surgery and receiving general anesthesia. Patients received ondansetron 4mg i.v. prior to a standardized technique for induction and intubation. Anesthesia was maintained with N2O-O2 and enflurane. The results showed that, by ondansetron 4mg, nausea and emesis could be significantly decreased. The effect lasted around 24h postoperatively without sedation. No one developed vomiting and only 9 patients developed nausea. No changes on laboratory parameters as well as vital signs were observed. No side-effects related to ondansetron were found. In prophylaxis of postoperative nausea and vomiting, ondansetron is effective and safe.
对65例接受择期腹部手术并接受全身麻醉的美国麻醉医师协会（ASA）I-III级患者，研究了预防性静脉注射昂丹司琼预防术后恶心和呕吐的有效性及安全性。患者在采用标准化诱导和插管技术前静脉注射4mg昂丹司琼。麻醉维持采用N2O-O2和安氟醚。结果显示，静脉注射4mg昂丹司琼可显著减少恶心和呕吐。该效果在术后持续约24小时，且无镇静作用。无人发生呕吐，仅9例患者出现恶心。未观察到实验室参数及生命体征有变化。未发现与昂丹司琼相关的副作用。在预防术后恶心和呕吐方面，昂丹司琼有效且安全。
