Wang Z, Chen J Q, Zheng H L
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou.
Zhonghua Yan Ke Za Zhi. 1994 May;30(3):218-20.
The specimens of the corneal lesions and their adjacent bulbar conjunctivas taken from 14 cases with Mooren's ulcers were studied by immunohistochemical techniques to investigate the expression of HLA-DR antigen and the subgroups of lymphocytes. It is discovered that there is an aberrant expression of HLA-DR antigen in a large amount of keratoconjunctival epithelial cells and stromal keratocytes and simultaneously, the CD4/CD8 ratio is significantly higher than that of the normal control group. The results suggest that the aberrant expression of MHC-II antigen in the resident cells at the peripheral cornea and its adjacent conjunctiva and a raised local TH/TS ratio leading to an excessive autoimmune reactivity be possibly the direct cause of the pathogenesis of the Mooren's ulcer.
采用免疫组化技术对14例蚕蚀性角膜溃疡患者的角膜病变及其邻近球结膜标本进行研究，以探讨HLA - DR抗原的表达及淋巴细胞亚群情况。发现大量角膜结膜上皮细胞和角膜基质细胞中存在HLA - DR抗原异常表达，同时CD4/CD8比值显著高于正常对照组。结果提示，周边角膜及其邻近结膜中固有细胞的MHC - II抗原异常表达以及局部TH/TS比值升高导致自身免疫反应过度，可能是蚕蚀性角膜溃疡发病的直接原因。
