Regoli F, Orlando E
Dipartimento di Biomedicina Sperimentale, Infettiva e Pubblica, Università di Pisa, Italy.
Environ Health Perspect. 1994 Sep;102 Suppl 3(Suppl 3):335-8. doi: 10.1289/ehp.94102s3335.
The possible risk for human health arising from consumption of lead-polluted shellfish was suggested by experiments on the bioavailability for mice of a "biologically detoxified" form of the metal. In this work, young mice were fed with a mixed diet including mussels collected in a Pb-polluted area. Metal concentrations in blood, kidney, liver, urine, and feces and the activity of erythrocytic delta-aminolevulinic acid dehydratase were determined after 1, 2, and 4 weeks. Comparisons were made with mice treated with balanced diet, mixed diet including control mussels, and drinking water with lead dissolved as acetate. In mice fed polluted mussels, lead concentrations increased in blood, kidney, and liver, whereas no significant accumulation was observed in urine. Different responses in mice treated with Pb(CH3COO)2 in drinking water are probably due to the diversity of lead chemical form in the two treatments. Our results demonstrate the bioavailability of biologically detoxified lead that can be transferred to a consumer with possible consequences also for human health.
对金属“生物解毒”形式在小鼠体内生物可利用性的实验表明，食用铅污染贝类可能对人类健康构成风险。在这项研究中，给幼鼠喂食混合饲料，其中包括在铅污染区域采集的贻贝。在1周、2周和4周后，测定血液、肾脏、肝脏、尿液和粪便中的金属浓度以及红细胞δ-氨基乙酰丙酸脱水酶的活性。将其与食用均衡饮食、食用含对照贻贝的混合饮食以及饮用溶解有醋酸铅的水的小鼠进行比较。在喂食受污染贻贝的小鼠中，血液、肾脏和肝脏中的铅浓度升高，而尿液中未观察到明显的积累。饮用水中添加醋酸铅处理的小鼠出现不同反应，可能是由于两种处理中铅化学形态的差异。我们的结果证明了生物解毒铅的生物可利用性，这种铅可以转移到消费者体内，也可能对人类健康产生影响。
