Hay A J, Douglas A R, Sparrow D B, Cameron K R, Skehel J J
National Institute for Medical Research, Mill Hill, London, UK.
Eur J Epidemiol. 1994 Aug;10(4):465-6. doi: 10.1007/BF01719677.
Annually the influenza centre receives more than 1000 virus isolates from around the world to monitor the changing pattern of viruses causing influenza throughout the year. These are characterized antigenically using both polyclonal and monoclonal antibodies and selected viruses are subjected to closer scrutiny by nucleotide sequence analyses of their HA genes. This information is used in making the annual recommendation of vaccine composition. As in the last 15 years, influenza A viruses of both H3N2 and H1N1 subtypes and influenza B viruses have been isolated during the recent influenza season. Outbreaks in the northern hemisphere were largely caused by influenza B viruses which are similar to the B/Panama/45/90 reference strain. The proportion of influenza A increased later in the season and was predominantly of the H3N2 subtype, viruses similar to the recent A/Beijing/32/92 variant being most prevalent. The observed changes taking place will be discussed in the context of recent trends.
流感中心每年从世界各地接收1000多个病毒分离株，以监测全年引起流感的病毒变化模式。使用多克隆和单克隆抗体对这些病毒进行抗原特性鉴定，并通过对其HA基因进行核苷酸序列分析，对选定的病毒进行更仔细的检查。这些信息用于提出年度疫苗成分建议。与过去15年一样，在最近的流感季节中分离出了H3N2和H1N1亚型的甲型流感病毒以及乙型流感病毒。北半球的疫情主要由与B/巴拿马/45/90参考毒株相似的乙型流感病毒引起。甲型流感的比例在本季节后期有所增加，主要是H3N2亚型，与最近的A/北京/32/92变异株相似的病毒最为普遍。将结合近期趋势讨论观察到的变化。
