乙型流感病毒在前期波峰期和后期流行季节的血凝素（HA）基因比较。
Comparison of the HA genes of type B influenza viruses in herald waves and later epidemic seasons.
作者信息
Nakajima S, Nishikawa F, Nakamura K, Nakajima K
机构信息
Institute of Public Health, Tokyo, Japan.
出版信息
Epidemiol Infect. 1992 Dec;109(3):559-68. doi: 10.1017/s0950268800050548.
From January 1985 to May 1991, herald strains of influenza B virus were isolated in 1987 and 1989 in Japan. In both cases, influenza epidemics caused by the same type followed in the next winter season. The HA gene sequences of the influenza B viruses isolated in Japan from 1987-91, which covers two herald waves of influenza B viruses, were analysed and located on the phylogenetic tree for influenza B viruses after the B/Singapore/64 strain. Co-circulation of at least two evolutionary lineages of the HA genes existed for influenza B viruses in Japan during the period of this study. The herald viruses in one wave (1987) were genetically close to the winter isolates and were considered to be the parental viruses for the following influenza season, while in the other wave (1989) winter isolates belonged to another lineage on which one of the herald viruses was located, but they were genetically and antigenically different from the herald viruses.
1985年1月至1991年5月期间，1987年和1989年在日本分离出了乙型流感病毒的先驱毒株。在这两起案例中，次年冬季都出现了由同一类型引起的流感流行。对1987年至1991年在日本分离出的乙型流感病毒的HA基因序列进行了分析，这些序列涵盖了两波乙型流感病毒的先驱毒株，并在B/新加坡/64毒株之后的乙型流感病毒系统发育树上定位。在本研究期间，日本的乙型流感病毒存在至少两个HA基因进化谱系的共同流行。其中一波（1987年）的先驱病毒在基因上与冬季分离株接近，被认为是随后流感季节的亲本病毒，而在另一波（1989年）中，冬季分离株属于先驱病毒所在的另一个谱系，但它们在基因和抗原上与先驱病毒不同。
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