Borini A, Bafaro G, Violini F, Bianchi L, Casadio V, Flamigni C
Reproductive Medicine Unit, University of Bologna, Italy.
Fertil Steril. 1995 Feb;63(2):258-61.
To determine the potential of the aging uterus in terms of pregnancy, implantation, and abortion rates, and obstetric complications in postmenopausal women age 50 and over, receiving oocyte donation.
Retrospective data analysis.
A tertiary infertility center.
Thirty-four postmenopausal women (50 to 62 years of age) undergoing a total of 61 cycles of oocyte donation.
Hormone replacement therapy (HRT) was given using increasing doses of 17 beta-E2 (2, 4, and 6 mg) and 100 mg of P in oil.
Pregnancy, abortion, and implantation rates, and pregnancy outcome.
There were 34 patients treated through 61 cycles. Fifty-five transfer cycles were performed. A total of 18 clinical pregnancies were achieved with a pregnancy rate per transfer of 32.7% and per patient of 52.9%. There was one abortion, resulting in an abortion rate of 5.5%. Twenty-one of the 116 transferred embryos implanted, resulting in an implantation rate of 18%. No statistically different rates were found in oocytes donors.
Women over the age of 50 and up to 62 can become pregnant using donated oocytes. The aging uterus after HRT allows implantation as well as in young women, and it is able to carry pregnancy to term apparently without any problems.
确定50岁及以上接受卵母细胞捐赠的绝经后妇女的子宫在妊娠、着床及流产率方面的潜能，以及产科并发症情况。
回顾性数据分析。
一家三级不孕不育中心。
34名绝经后妇女（年龄50至62岁），共接受61个周期的卵母细胞捐赠。
采用递增剂量的17β-雌二醇（2毫克、4毫克和6毫克）及100毫克油剂黄体酮进行激素替代疗法（HRT）。
妊娠率、流产率、着床率及妊娠结局。
34名患者接受了61个周期的治疗。共进行了55次移植周期。总共实现了18例临床妊娠，每次移植的妊娠率为32.7%，每名患者的妊娠率为52.9%。发生1例流产，流产率为5.5%。116个移植胚胎中有21个着床，着床率为18%。卵母细胞捐赠者的各项比率无统计学差异。
50岁至62岁的妇女使用捐赠卵母细胞能够怀孕。激素替代疗法后的衰老子宫与年轻女性的子宫一样能够实现着床，并且显然能够毫无问题地将妊娠维持至足月。
