Goldenberg I, Shoshani O, Mushkat Y, Bentur Y, Melamed Y, Shupak A
Israel Naval Medical Institute, Rambam Medical Center, Haifa.
Harefuah. 1994 Nov 1;127(9):300-2, 360.
Hydrogen sulfide (H2S) is a toxic gas produced in decaying substances containing organic sulfur. Exposure to the gas causes severe disturbances in the central nervous and respiratory systems. The mechanism of toxicity is disruption of the electron transport chain in mitochondria, resulting in intracellular hypoxia. Treatment of H2S poisoning includes mechanical ventilation with 100% oxygen and immediate administration of sodium nitrate. Treatment with hyperbaric oxygen (HBO) has been studied in animal models, and has also been used in a number of patients. However, the clinical effectiveness of this mode of therapy has not been clearly proven. Having recently treated a case of H2S poisoning, we suggest HBO to reduce mortality.
硫化氢（H₂S）是一种在含有有机硫的腐烂物质中产生的有毒气体。接触该气体会导致中枢神经系统和呼吸系统严重紊乱。毒性机制是线粒体中电子传递链的破坏，导致细胞内缺氧。硫化氢中毒的治疗包括用100%氧气进行机械通气并立即给予硝酸钠。高压氧（HBO）治疗已在动物模型中进行研究，也已用于一些患者。然而，这种治疗方式的临床有效性尚未得到明确证实。最近我们治疗了一例硫化氢中毒病例，我们建议使用高压氧以降低死亡率。
