Auslaender S, Barzilay A, Trau H
Dermatology Dept., Chaim Sheba Medical Center, Tel Hashomer.
Harefuah. 1994 Nov 1;127(9):303-5, 360, 359.
Porokeratosis is a chronic, progressive disease of hereditary origin, characterized by the formation of annular, flat lesions with elevated scaly borders. It appears as a few clinical variants that differ mainly in the mode of spread of the lesions and age of onset. In recent years immunosuppression has been found to initiate appearance of the disease or cause its exacerbation. We present a 39-year-old man who developed porokeratosis a year after commencing immunosuppressive treatment following a heart transplantation. There is a relationship between the immune system, malignant transformation and porokeratosis.
汗孔角化症是一种遗传性慢性进行性疾病,其特征为形成边界有鳞屑隆起的环形扁平损害。它表现为几种临床变异型,主要在损害的扩散方式和发病年龄方面有所不同。近年来发现免疫抑制可引发该病出现或导致其加重。我们报告一名39岁男性,在心脏移植后开始免疫抑制治疗一年后发生了汗孔角化症。免疫系统、恶性转化与汗孔角化症之间存在关联。