Kasagi F, Akahoshi M, Shimaoka K
Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
Hypertension. 1995 Jan;25(1):71-6. doi: 10.1161/01.hyp.25.1.71.
The present study examined the relation between blood pressure reactivity to cold stimulus and the subsequent development of hypertension based on a follow-up study from 1960 through 1988 of 824 normotensive participants (mean age, 35.8 +/- 10.8 years) in the Adult Health Study in Nagasaki, Japan. Hypertension developed in 343 individuals during the 28 years of follow-up, with a mean incidence rate of 24.6 per 10(3) person-years. Confounding variables, including attained age, resting systolic and diastolic blood pressures, and body mass index at baseline, were adjusted using a Poisson regression model. Systolic response was found to be an independent and significant predictor. The relative risk of hypertension for systolic hyperreactors was 1.37, with a 95% confidence interval of 1.10 to 1.71. Diastolic response was significant only when resting diastolic blood pressure was also considered. The cold pressor test appears to be useful if performed on middle-aged subjects older than 40 years at the time of examination, when hypertension is more prevalent. The current results support the hypothesis that hyperreactivity is a predictor of the development of hypertension.
本研究基于对日本长崎成人健康研究中824名血压正常参与者（平均年龄35.8±10.8岁）从1960年至1988年的随访研究，探讨了冷刺激下的血压反应性与随后高血压发生之间的关系。在28年的随访期间，343人患上了高血压，平均发病率为每10³人年24.6例。使用泊松回归模型对包括达到的年龄、静息收缩压和舒张压以及基线时的体重指数等混杂变量进行了调整。发现收缩压反应是一个独立且显著的预测因素。收缩压高反应者患高血压的相对风险为1.37，95%置信区间为1.10至1.71。仅在同时考虑静息舒张压时，舒张压反应才具有显著性。如果在检查时对40岁以上的中年受试者进行冷加压试验，此时高血压更为普遍，那么该试验似乎是有用的。目前的结果支持高反应性是高血压发生的预测因素这一假设。
