Saxena Indu, Kumar Manoj, Srivastava Nandini, Srivastava Sameer, Sen Aniruddha, Arvind Ashish, Kaur Amar Preet
Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Gorakhpur, IND.
Department of Physiology, Maharshi Vashishtha Autonomous State Medical College, Basti, Basti, IND.
Cureus. 2024 Jul 27;16(7):e65518. doi: 10.7759/cureus.65518. eCollection 2024 Jul.
The intensity of pain perceived for the same noxious stimulus is different in different persons, depending on the biological, psychological, and social factors related to the individual. In clinical practice, it is important to know the factors influencing pain perception. The presence of anemia may affect pain perception.
This study was conducted on 73 female subjects of whom 25 were non-anemic, 24 had mild, and 24 had moderate anemia. Experimental pain was produced by cold pressor task (CPT). Pain response was evaluated in terms of cardiovascular reactivity (CVR - changes in blood pressure and heart rate), and pain sensitivity (PS - pain threshold, pain tolerance, and pain rating).
Anemic subjects showed higher CVR to stress. The average increase in systolic blood pressure was 5.28 mm of Hg in non-anemic, compared to 3.25 in mildly anemic and 9.00 mm of Hg in moderately anemic subjects. The average increase in diastolic blood pressure was 2.24 mm of Hg in non-anemic, 2.5 in mildly anemic, and 4.83 mm of Hg in moderately anemic subjects. The average increase in heart rate was 2.88 beats per minute (bpm) in non-anemic, 4.83 in mildly anemic, and 7 bpm in moderately anemic subjects. Pain rating was higher in anemic subjects (average 7.21) compared to the non-anemic subjects (average 6.44).
CPT-induced pain causes greater cardiovascular reactivity in anemic patients. The average pain rating is higher in anemic subjects.
对于相同的有害刺激，不同个体所感受到的疼痛强度不同，这取决于与个体相关的生物学、心理学和社会因素。在临床实践中，了解影响疼痛感知的因素很重要。贫血的存在可能会影响疼痛感知。
本研究对73名女性受试者进行，其中25名无贫血，24名患有轻度贫血，24名患有中度贫血。通过冷加压试验（CPT）产生实验性疼痛。根据心血管反应性（CVR - 血压和心率变化）和疼痛敏感性（PS - 疼痛阈值、疼痛耐受性和疼痛评分）评估疼痛反应。
贫血受试者对压力表现出更高的CVR。非贫血受试者收缩压平均升高5.28毫米汞柱，轻度贫血受试者为3.25毫米汞柱，中度贫血受试者为9.00毫米汞柱。非贫血受试者舒张压平均升高2.24毫米汞柱，轻度贫血受试者为2.5毫米汞柱，中度贫血受试者为4.83毫米汞柱。非贫血受试者心率平均升高2.88次/分钟（bpm），轻度贫血受试者为4.83次/分钟，中度贫血受试者为7次/分钟。贫血受试者的疼痛评分（平均7.21）高于非贫血受试者（平均6.44）。
CPT诱导的疼痛在贫血患者中引起更大的心血管反应性。贫血受试者的平均疼痛评分更高。
