FR901451，一种源自弯曲杆菌属的新型人白细胞弹性蛋白酶抑制剂。I. 产生菌、发酵、分离、理化性质及生物学特性
FR901451, a novel inhibitor of human leukocyte elastase from Flexibacter sp. I. Producing organism, fermentation, isolation, physico-chemical and biological properties.
作者信息
Fujita T, Hatanaka H, Hayashi K, Shigematsu N, Takase S, Okamoto M, Okuhara M, Shimatani K, Satoh A
机构信息
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
出版信息
J Antibiot (Tokyo). 1994 Dec;47(12):1359-64. doi: 10.7164/antibiotics.47.1359.
PMID:7844029
Abstract
A novel human leukocyte elastase (HLE) inhibitor, FR901451 was discovered in the fermentation broth of a bacteria. The bacteria was identified as Flexibacter sp. No. 758. FR901451 has a molecular weight of 1269 and a molecular formula of C60H79N13O18. The mode of inhibition against HLE is competitive, with a Ki value of 9.8 x 10(-9) M.
摘要
一种新型人白细胞弹性蛋白酶（HLE）抑制剂FR901451是在一种细菌的发酵液中发现的。该细菌被鉴定为Flexibacter sp. No. 758。FR901451的分子量为1269，分子式为C60H79N13O18。其对HLE的抑制模式为竞争性抑制，Ki值为9.8×10⁻⁹ M。
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