Chaturvedi S, Frame P, Newman S L
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio.
J Infect Dis. 1995 Feb;171(2):320-7. doi: 10.1093/infdis/171.2.320.
The phagocytic and fungistatic activity of monocyte-derived macrophages from human immunodeficiency virus (HIV)-positive persons against Histoplasma capsulatum yeasts was determined. Macrophages from HIV-positive patients were profoundly deficient in their capacity to recognize and bind H. capsulatum, but ingestion of bound yeasts was normal. The binding of H. capsulatum by patient macrophages tended to decrease with a decrease in CD4+ T lymphocyte counts. Another major defect was that patient macrophages were more permissive for the intracellular growth of H. capsulatum. Macrophages from 22 of 58 patients showed a > or = 2-fold increase in intracellular growth compared with control macrophages. Thus, in addition to defects in cell-mediated immunity caused by a loss of CD4+ T cells, macrophages from HIV-positive patients exhibit intrinsic defects in macrophage function against H. capsulatum that may contribute to the increased susceptibility of HIV-positive patients to disseminated histoplasmosis.
测定了来自人类免疫缺陷病毒（HIV）阳性者的单核细胞衍生巨噬细胞对荚膜组织胞浆菌酵母的吞噬和抑真菌活性。HIV阳性患者的巨噬细胞在识别和结合荚膜组织胞浆菌的能力上严重不足，但对已结合酵母的摄取正常。患者巨噬细胞对荚膜组织胞浆菌的结合倾向于随着CD4 + T淋巴细胞计数的减少而降低。另一个主要缺陷是患者巨噬细胞对荚膜组织胞浆菌的细胞内生长更具耐受性。58名患者中有22名患者的巨噬细胞与对照巨噬细胞相比，细胞内生长增加了2倍或更多。因此，除了由CD4 + T细胞丧失引起的细胞介导免疫缺陷外，HIV阳性患者的巨噬细胞对荚膜组织胞浆菌的巨噬细胞功能存在内在缺陷，这可能导致HIV阳性患者对播散性组织胞浆菌病的易感性增加。
