Shinha Takashi, Badem Olga
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center , Nashville, IN.
Department of Medicine, Wyckoff Heights Medical Center , Brooklyn, NY, USA.
Infect Dis Rep. 2015 Mar 3;7(1):5747. doi: 10.4081/idr.2015.5747. eCollection 2015 Feb 24.
In HIV-infected individuals, macrophages, the key defense effector cells, manifest defective activity in their interactions with a wide variety of opportunistic pathogens, including fungi and protozoa. Understanding the morphological characteristics of intracellular opportunistic pathogens in addition to their pathogenesis is of critical importance to provide optimal therapy, thereby decreasing morbidity and mortality in HIV-infected patients. We herein present a case of disseminated histoplasmosis confused with disseminated visceral leishmaniasis in an HIV-infected individual from Guyana who developed intracellular organisms within alveolar macrophages.
在HIV感染个体中，作为关键防御效应细胞的巨噬细胞，在与包括真菌和原生动物在内的多种机会性病原体相互作用时表现出功能缺陷。除了了解细胞内机会性病原体的发病机制外，了解其形态特征对于提供最佳治疗至关重要，从而降低HIV感染患者的发病率和死亡率。我们在此报告一例来自圭亚那的HIV感染个体，其播散性组织胞浆菌病被误诊为播散性内脏利什曼病，该患者在肺泡巨噬细胞内发现了细胞内生物体。
