Abdel Rahman M M, el-Hakim M S, Ahmed M K, Saleh S A, Arafa M M
Department of Tropical Medicine, Faculty of Medicine, Al Azhar University, Cairo.
J Egypt Soc Parasitol. 1994 Dec;24(3):633-41.
No doubt chronic liver diseases due to schistosomiasis and other causes as virus hepatitis are not uncommon among Egyptian patients. Besides, neoplastic changes in such patients are always seen. So, the aim of this work was to evaluate the estimation of hepatocytes DNA in chronic liver diseases as a diagnostic feature for early preneoplastic changes in different groups of patients. These groups included (a) chronic persistent hepatitis, (b) chronic active hepatitis, (c) liver cirrhosis due to schistosomiasis and other causes & (d) hepatocellular carcinoma. The results were evaluated histochemically and histopathologically. It was concluded that the cytophotometic evidence of hepatocytes DNA in chronic liver diseases is a promising mean in detecting early preneoplastic changes.
毫无疑问，在埃及患者中，由血吸虫病以及其他病因如病毒性肝炎引起的慢性肝病并不罕见。此外，这类患者中也总能见到肿瘤性病变。因此，本研究的目的是评估慢性肝病中肝细胞DNA的测定，作为不同患者组早期癌前病变的诊断特征。这些组包括：（a）慢性持续性肝炎，（b）慢性活动性肝炎，（c）由血吸虫病和其他病因引起的肝硬化，以及（d）肝细胞癌。对结果进行了组织化学和组织病理学评估。得出的结论是，慢性肝病中肝细胞DNA的细胞光度测定证据是检测早期癌前病变的一种有前景的手段。
