Dethloff L A, Altrogge D M, Gillhouse K A
Department of Pathology and Experimental Toxicology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48104.
Lab Anim Sci. 1994 Oct;44(5):468-71.
Gastric acid secretion was measured in male and female cynomolgus monkeys under basal conditions and in response to intravenous administration of pentagastrin (PG). There were no statistically significant differences between males and females in either basal or PG-stimulated gastric acid output. Neither were differences between males and females statistically significant when adjusted according to body weight. For both sexes combined, basal acid output was 17 +/- 20 muEq/h. Intravenous infusion of PG stimulated gastric acid secretion at dose rates of 1 micrograms/kg/h and greater. Maximal stimulation occurred at dose rates of 10 and 100 micrograms/kg/h, indicating gastric acid secretion plateaus above PG doses of 10 micrograms/kg. Acid secretion values in response to 100 micrograms of PG/kg/h for both sexes combined were 571 +/- 132 and 400 +/- 135 muEq/kg/h for peak acid output and maximum acid output, respectively. These data suggest that the cynomolgus monkey may be a useful model for gastric physiology studies of relevance to human beings.
在基础条件下以及静脉注射五肽胃泌素（PG）后，对雄性和雌性食蟹猴的胃酸分泌进行了测量。在基础胃酸分泌或PG刺激的胃酸分泌方面，雄性和雌性之间均无统计学上的显著差异。根据体重进行调整后，雄性和雌性之间的差异也无统计学意义。对于两性而言，基础胃酸分泌量为17±20微当量/小时。静脉输注PG在剂量率为1微克/千克/小时及以上时刺激胃酸分泌。最大刺激发生在剂量率为10和100微克/千克/小时时，表明在PG剂量高于10微克/千克时胃酸分泌达到平台期。两性联合使用时，对100微克/千克/小时PG的反应，峰值胃酸分泌量和最大胃酸分泌量的酸分泌值分别为571±132和400±135微当量/千克/小时。这些数据表明，食蟹猴可能是与人类相关的胃生理学研究的有用模型。
