Konstadoulakis M M, Ricaniadis N, Walsh D, Karakousis C P
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263.
J Surg Oncol. 1995 Feb;58(2):118-20. doi: 10.1002/jso.2930580209.
The charts of 15 patients with malignant melanoma of the anorectal region treated at Roswell Park Cancer Institute in the period 1975-1991 were reviewed. All the lesions except one developed at the pectinate line, in the area of transitional mucosa. Two of the patients at the time of initial presentation had distant metastases. Of the remaining 13, 8 were treated with abdominoperineal resection (APR) and 5 with local excision (LE). The incidence of local recurrence was 50% in the LE group and 22% in the APR group. Patients treated with APR had a 25%, 5-year survival rate compared with 0% for those treated with LE, although one of the latter group died 55 months following LE due to unrelated causes without recurrence. The median survival of those with LE was 15.7 months and of those with APR 13.7 months.
回顾了1975年至1991年期间在罗斯韦尔公园癌症研究所接受治疗的15例肛管直肠区域恶性黑色素瘤患者的病历。除1例病变外，所有病变均发生在齿状线、移行黏膜区域。2例患者初诊时已有远处转移。其余13例中，8例行腹会阴联合切除术（APR），5例行局部切除术（LE）。LE组局部复发率为50%，APR组为22%。接受APR治疗的患者5年生存率为25%，而接受LE治疗的患者5年生存率为0%，尽管后一组中有1例在LE治疗后55个月因无关原因死亡，未出现复发。接受LE治疗的患者中位生存期为15.7个月，接受APR治疗的患者中位生存期为13.7个月。
