Peiper M, Rogiers X, Zornig C
Abteilung für Allgemeinchirurgie, Universitäts-Krankenhaus Eppendorf, Hamburg.
Langenbecks Arch Chir. 1994;379(6):368-71.
Eleven adult patients with primary sarcoma of the liver underwent surgery at the University Hospital of Hamburg-Eppendorf between 1985 and January 1994. In 8 cases it was possible to resect the tumor with wide margins (R0), in 1 of these in the course of orthotopic liver transplantation. Three patients had primarily marginal resection (R1). By the end of the study period 7 of the patients who underwent initial R0 resection are tumor-free, with a mean survival time of 57 (5-104) months. The patient with orthotopic liver transplantation developed metastases 31 months after primary surgery. At 7 months after initial R1 resection, 1 patient is alive with no evidence of disease while 2 others died after 30 and 35 months, respectively. Patients with non-metastasized, primary sarcomas of the liver can expect long-term survival if the tumor is resected with wide margins in an anatomical hepatectomy. In the case of multifocal growth in the liver transplantation can be considered.
1985年至1994年1月期间,11例原发性肝脏肉瘤成年患者在汉堡-埃彭多夫大学医院接受了手术。8例患者能够进行切缘阴性(R0)的肿瘤切除,其中1例是在原位肝移植过程中进行的。3例患者最初进行了切缘阳性切除(R1)。到研究期结束时,最初接受R0切除的患者中有7例无瘤生存,平均生存时间为57(5 - 104)个月。原位肝移植患者在初次手术后31个月出现转移。在初次R1切除后7个月,1例患者存活且无疾病证据,另外2例分别在30个月和35个月后死亡。对于未发生转移的原发性肝脏肉瘤患者,如果在解剖性肝切除术中切缘阴性切除肿瘤,有望获得长期生存。如果肝脏存在多灶性生长,可考虑肝移植。