Meyer K B, Madias N E
Department of Medicine, New England Medical Center, Boston, MA 02111.
Miner Electrolyte Metab. 1994;20(4):201-13.
Cisplatin treatment causes tubulointerstitial injury to the kidneys. Common clinical syndromes associated with its use include acute renal failure and a magnesium wasting state. Routine fluid infusion therapy has markedly reduced the incidence of acute renal failure. However, methodologic limitations of most recent studies preclude confident conclusions regarding long-term effects of cisplatin treatment on renal function. Experimental and clinical evidence suggests that sulfhydryl metabolism and oxidative stress are central to cisplatin renal injury. Both in animals and humans, a variety of agents appear to alter renal uptale of cisplatin and its hemodynamic consequences, thus modulating nephrotoxicity. Thiosulfates and related agents have received most study. Other agents examined have included calcium channel blockers, bismuth, selenium, glycine, cimetidine, and probenecid.
顺铂治疗会导致肾脏的肾小管间质损伤。与其使用相关的常见临床综合征包括急性肾衰竭和镁消耗状态。常规的液体输注疗法已显著降低了急性肾衰竭的发生率。然而，最近大多数研究的方法学局限性使得关于顺铂治疗对肾功能长期影响的可靠结论难以得出。实验和临床证据表明，巯基代谢和氧化应激是顺铂肾损伤的核心。在动物和人类中，多种药物似乎会改变顺铂的肾脏摄取及其血流动力学后果，从而调节肾毒性。硫代硫酸盐及相关药物得到了最多的研究。其他研究过的药物包括钙通道阻滞剂、铋、硒、甘氨酸、西咪替丁和丙磺舒。
