MK-801抑制大脑中动脉闭塞后大脑皮层、丘脑和海马中即刻早期基因的诱导，但不抑制黑质中即刻早期基因的诱导。

MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus, and hippocampus, but not in substantia nigra following middle cerebral artery occlusion.

作者信息

Kinouchi H, Sharp F R, Chan P H, Mikawa S, Kamii H, Arai S, Yoshimoto T

机构信息

Division of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Neurosci Lett. 1994 Sep 26;179(1-2):111-4. doi: 10.1016/0304-3940(94)90947-4.

DOI:10.1016/0304-3940(94)90947-4

PMID:7845604

Abstract

Middle cerebral artery (MCA) occlusion in rats induced c-fos and junB mRNA 4h later in all ipsilateral cortex outside the MCA distribution and in many subcortical structures: medial striatum; most of thalamus including medial and lateral geniculate nuclei: substantia nigra; and hippocampus. The N-methyl-D-aspartate (NMDA) antagonist, MK-801 (4 mg/kg, i.p.) inhibited c-fos and junB mRNA induction in the cortex, striatum, thalamus, and hippocampus but not in the substantia nigra. These data show that c-fos and junB mRNA induction in cortex, striatum, thalamus, hippocampus involves the activation of NMDA receptors whereas different receptors must be implicated in the induction in substantia nigra.

摘要

大鼠大脑中动脉（MCA）闭塞4小时后，在MCA分布区域外的所有同侧皮质以及许多皮质下结构中诱导了c-fos和junB mRNA的表达，这些结构包括：内侧纹状体；大部分丘脑，包括内侧和外侧膝状体核；黑质；以及海马体。N-甲基-D-天冬氨酸（NMDA）拮抗剂MK-801（4毫克/千克，腹腔注射）抑制了皮质、纹状体、丘脑和海马体中c-fos和junB mRNA的诱导，但对黑质没有影响。这些数据表明，皮质、纹状体、丘脑和海马体中c-fos和junB mRNA的诱导涉及NMDA受体的激活，而黑质中的诱导必定涉及不同的受体。