Verbanac J S, Commissaris R L, Altman H J, Pitts D K
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Wayne State University, Detroit, MI 48202.
Neurosci Lett. 1994 Sep 26;179(1-2):137-40. doi: 10.1016/0304-3940(94)90953-9.
Extracellular single-unit recording techniques were used to evaluate the physiological and pharmacological characteristics of noradrenergic locus coeruleus (LC) neurons in urethane-anesthetized Maudsley reactive (MR) and non-reactive (MNRA) rat strains, a presumed genetic model for differences in 'anxiety'. LC neurons from MNRA rats were found to have a significantly higher basal discharge rate than LC neurons from either the MR or Sprague-Dawley (SD) rats. The discharge pattern of MNRA LC neurons also differed significantly from that of LC neurons from SD and MR rats, with LC neurons from MNRA rats exhibiting a burst-like pattern of discharge. Finally, MNRA LC neurons were significantly less sensitive to the inhibitory effects of i.v. clonidine on spontaneous activity.
采用细胞外单单位记录技术，评估了在乌拉坦麻醉的莫兹利反应性（MR）和非反应性（MNRA）大鼠品系中去甲肾上腺素能蓝斑（LC）神经元的生理和药理学特性，这是一种推测的“焦虑”差异遗传模型。发现MNRA大鼠的LC神经元的基础放电率显著高于MR大鼠或斯普拉格-道利（SD）大鼠的LC神经元。MNRA LC神经元的放电模式也与SD和MR大鼠的LC神经元有显著差异，MNRA大鼠的LC神经元表现出爆发样放电模式。最后，MNRA LC神经元对静脉注射可乐定对自发活动的抑制作用明显不敏感。
