前列腺切除术对成年白化大鼠睾丸雄激素生成及血清促性腺激素水平的影响。

Effects of prostatectomy on testicular androgenesis and serum levels of gonadotropins in mature albino rats.

作者信息

Ghosh P K, Ghosh D, Ghosh P, Chaudhuri A

机构信息

Department of Surgery, Ohio State University, Columbus 43210.

出版信息

Prostate. 1995 Jan;26(1):19-22. doi: 10.1002/pros.2990260105.

DOI:10.1002/pros.2990260105

PMID:7845863

Abstract

The effects of prostatectomy on testicular steroidogenic enzymes, and on serum levels of gonadotropins, prolactin, and testosterone were studied. Adult male rats were prostatectomized and sacrificed after 14 and 21 days. There was augmentation of both delta 5-3 beta-hydroxysteroid dehydrogenase (delta 5-3 beta-HSD) and 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activities in the testes along with increased levels of FSH, prolactin, and testosterone in the serum, while no changes were observed in serum levels of LH. Hence it may be concluded that the prostate gland has an inhibitory effect on testicular androgenesis and can exert some influence in the regulation of FSH and prolactin secretion.

摘要

研究了前列腺切除术对睾丸类固醇生成酶以及促性腺激素、催乳素和睾酮血清水平的影响。成年雄性大鼠接受前列腺切除术后，分别于14天和21天后处死。睾丸中δ5-3β-羟基类固醇脱氢酶（δ5-3β-HSD）和17β-羟基类固醇脱氢酶（17β-HSD）的活性均增强，同时血清中促卵泡激素、催乳素和睾酮水平升高，而血清中促黄体生成素水平未观察到变化。因此，可以得出结论，前列腺对睾丸雄激素生成具有抑制作用，并且对促卵泡激素和催乳素的分泌调节可能有一定影响。