Widmark A, Grankvist K, Bergh A, Henriksson R, Damber J E
Department of Oncology, Umeå University, Sweden.
Prostate. 1995 Jan;26(1):5-11. doi: 10.1002/pros.2990260103.
The effects of estrogens and progestogens in the management of prostatic adenocarcinoma are generally believed to be related to their suppressive effect on the hypothalamic-pituitary-testicular axis, but other mechanisms have also been suggested. The present study was designed to investigate if an androgen-insensitive human prostatic cancer cell line (PC-3) is sensitive to estrogens or progestogens and to elucidate possible mechanisms of action. Both estrogens and progestogens in high doses (10(-5) M) suppressed tumor cell growth. At these high doses medroxyprogesterone acetate (MPA) most effectively reduced the uptake of 86rubidium chloride, indicating the strongest effect on ion transport and membrane permeability. Effects on rubidium transport were also seen after estrogen treatment. It is suggested that estrogens and progestogens have direct cytotoxic effects on prostatic carcinoma cells in vitro, possibly by an effect on the cell membrane.
雌激素和孕激素在前列腺腺癌治疗中的作用通常被认为与其对下丘脑 - 垂体 - 睾丸轴的抑制作用有关，但也有人提出了其他机制。本研究旨在调查雄激素不敏感的人前列腺癌细胞系（PC - 3）是否对雌激素或孕激素敏感，并阐明可能的作用机制。高剂量（10^(-5) M）的雌激素和孕激素均能抑制肿瘤细胞生长。在这些高剂量下，醋酸甲羟孕酮（MPA）最有效地降低了氯化铷的摄取，表明其对离子转运和膜通透性的影响最强。雌激素处理后也观察到对铷转运的影响。提示雌激素和孕激素在体外对前列腺癌细胞具有直接细胞毒性作用，可能是通过对细胞膜的作用实现的。
