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[用于植物保护的抗生素制剂杆菌素的吸入毒性]

[The inhalational toxicity of the antibiotic preparation Bactericin for plant protection].

作者信息

Khalkova Zh, Zaĭtsov Kh

出版信息

Probl Khig. 1993;18:105-14.

PMID:7845960
Abstract

The acute and subacute inhalation toxicity of a new Bulgarian antibiotic preparation "Bactericin" for plant protection is examined. It is meant for the treatment of seeds from tomatoes before sowing. The inhalational toxicity is evaluated by a complex of toxicometric, integral, behavioural, clinic-laboratory, biochemical and histological methods. The maximum concentration reached by dispersing is 40 mg.m-3. In the condition of acute (unrepeated exposure) and subacute (60 exposure) the concentration of 40 mg.m-3 causes no lethality, symptoms of intoxication and toxic effects in the organism of white rats therefore it could be accepted as not operative. The preparation conceals no danger of acute and chronic inhalational poisonings when working with the latter. On the basis of the performed investigations and bearing in mind, that the preparation is in the group of the antibiotics, a proposal is made for the purpose of orientation MAG in the air of the working zone -0.5 mg.m-3.

摘要

对一种用于植物保护的新型保加利亚抗生素制剂“杆菌素”的急性和亚急性吸入毒性进行了研究。它用于播种前处理番茄种子。吸入毒性通过一系列毒理学、综合、行为学、临床实验室、生物化学和组织学方法进行评估。分散后达到的最大浓度为40毫克/立方米。在急性(单次暴露)和亚急性(60次暴露)条件下,40毫克/立方米的浓度对白鼠机体未造成致死性、中毒症状和毒性作用,因此可认为其无活性。使用该制剂时不存在急性和慢性吸入中毒的危险。基于所进行的研究,并考虑到该制剂属于抗生素类,建议将工作区空气中的定向MAG设定为0.5毫克/立方米。

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