Khalkova Zh
Probl Khig. 1994;19:111-8.
The acute and subacute dermal toxicity, skin irritating and sensitizing effect of the preparation "Bulmektin" was examined for a period of 21 days. It contains 0.5% active substance Ivermectin. The experiments were carried out in conformity with the Bulgarian State Standards and the OECD methodical recommendations. The unrepeated dermal application of the preparation in dose 6000 mg/kg-1 for white rats provoked no lethality and signs of intoxication. No cumulative effect was established at the 21-day dermal toxicity. The threshold dose is 2000 mg/kg-1. On the basis of the investigations could be accepted, that the preparation carries no danger for acute and chronic dermal intoxications at observing the regulations for its production and use. No local irritation of the skin is established in rats and guinea pigs from the preparation. There is no development of contact allergy at the application of induced and allowed dose of 25% aqua suspension of the preparation on white guinea pigs.
对“布尔梅克汀”制剂进行了为期21天的急性和亚急性皮肤毒性、皮肤刺激和致敏作用研究。该制剂含有0.5%的活性物质伊维菌素。实验按照保加利亚国家标准和经合组织的方法建议进行。对白鼠以6000mg/kg-1的剂量进行单次皮肤给药未引发致死性和中毒迹象。在21天的皮肤毒性实验中未发现累积效应。阈剂量为2000mg/kg-1。根据研究结果可以认为，在遵守其生产和使用规定的情况下，该制剂对急性和慢性皮肤中毒无危险。该制剂对大鼠和豚鼠的皮肤未产生局部刺激。对白豚鼠使用25%该制剂水悬浮液的诱导剂量和许可剂量时，未发生接触性过敏。
