National Institutes of Health, University of the Philippines, Manila, Philippines.
J Occup Med Toxicol. 2007 Sep 18;2:9. doi: 10.1186/1745-6673-2-9.
This was a cross-sectional study which aimed to determine associations between hematologic indices such as red blood cell cholinesterase (RBC) and mean corpuscular volume (MCV), with illnesses related to pesticide exposure among cutflower farmers in La Trinidad, Benguet. One hundred two (102) randomly selected cutflower farmers underwent comprehensive, personal physical health and laboratory examinations and answered a questionnaire on work practices and illness. Majority were males (52%) and most belonged to the 20-35 age group (45%). Majority of exposed farmers were symptomatic, with most common complaints being headache (48%), easy fatigability (46.1%) and cough (40.2%). Analysis showed that RBC cholinesterase levels were positively associated with age (p = 0.02), and selling pesticide containers (p = 0.008). number of years of using pesticides (p = 0.022), use of contaminated cloth (p = 0.033), incorrect mixing of pesticides (p = 0.041), sex (p = 0.002) and illness due to pesticides (p = 0.005) were correlated with abnormal MCV. Significant associations were also found for hemoglobin, hematocrit, RBC, white blood cell (WBC) and platelet count. Predictors of RBC cholinesterase were years of pesticide use (p = 0.037) and abnormalities on health (p = 0.029). The findings of the study can be used for information dissemination and pesticide reduction programs for the cutflower farmers.
本研究为横断面研究,旨在探讨血细胞胆碱酯酶(RBC)和红细胞平均体积(MCV)等血液学指标与本地区切花种植户与农药暴露相关疾病的关联。本研究共纳入 102 名随机抽取的切花种植户,对其进行全面的个人身体健康和实验室检查,并通过问卷调查其工作实践和疾病情况。其中大部分为男性(52%),年龄主要集中在 20-35 岁(45%)。多数暴露于农药的种植户出现了症状,最常见的抱怨是头痛(48%)、易疲劳(46.1%)和咳嗽(40.2%)。分析表明 RBC 胆碱酯酶水平与年龄呈正相关(p = 0.02),与销售农药容器呈正相关(p = 0.008)。使用农药的年数(p = 0.022)、使用污染的布(p = 0.033)、不正确混合农药(p = 0.041)、性别(p = 0.002)和农药引起的疾病(p = 0.005)与 MCV 异常相关。血红蛋白、红细胞压积、红细胞、白细胞(WBC)和血小板计数也存在显著相关性。RBC 胆碱酯酶的预测因子为使用农药年限(p = 0.037)和健康异常(p = 0.029)。本研究结果可用于为切花种植户提供信息传播和农药减少计划。