Khalkova Zh
Probl Khig. 1996;21:74-80.
Studies for evaluation of the acute and subacute (21 day) dermal toxicity, skin-irritating, eye-irritating and skin-sensitizing effects of the preparation "Artishok" are carried out in order to determine the professional risk in direct skin contact during its production. The experiments are performed according to the Bulgarian standards and the requirements of OES. It is considered on the basis of the studies that the preparation is not able to produce dermal intoxications. The maximal single dose of 6000 mg.kg-1 is LD0. After 21 day dermal application of the preparation in doses 1000 and 3000 mg.kg-1 there are not observed any signs of intoxication, cumulative effect or changes in the integral, haematologic and biochemical studies of the white rats. These doses are considered to be inefficient. Neither skin-irritating nor eye-irritating effect has been proved. The determining of the skin-sensitizing potential of the preparation in guinea pigs through a maximizing test reveals lack of skin allergic reaction in the conditions of the experiment.
为确定生产过程中直接皮肤接触的职业风险，开展了关于制剂“Artishok”的急性和亚急性（21天）皮肤毒性、皮肤刺激性、眼睛刺激性和皮肤致敏性评估研究。实验按照保加利亚标准和职业接触限值要求进行。基于研究认为该制剂不会产生皮肤中毒。最大单剂量6000mg.kg-1为LD0。在以1000和3000mg.kg-1剂量对大鼠进行21天皮肤给药后，未观察到任何中毒迹象、累积效应或大鼠整体、血液学和生化研究的变化。这些剂量被认为是无效的。未证实有皮肤刺激性和眼睛刺激性作用。通过最大化试验测定该制剂在豚鼠中的皮肤致敏潜力，结果显示在实验条件下未出现皮肤过敏反应。
