Deakin J F
Department of Psychiatry, University of Manchester, UK.
Psychopathology. 1994;27(3-5):251-4. doi: 10.1159/000284878.
Schizophrenia is associated with structural changes in the brain but it is not clear whether the changes are localized. Studies in Manchester and elsewhere have reported abnormalities in biochemical markers of glutamate- and GABA-containing neurones in post-mortem brains from schizophrenic patients. The abnormalities occur in the ventral frontal cortex and anterior temporal lobe. It is suggested that these regions of the brain specifically encode information about social communication-language, gesture and facial expression. Many of the symptoms of schizophrenia become neuropsychologically understandable when seen as disturbances of social communication. In this and the following papers, experimental tests of this hypothesis are described.
精神分裂症与大脑结构变化有关，但尚不清楚这些变化是否局限于特定区域。曼彻斯特及其他地方的研究报告称，在精神分裂症患者死后的大脑中，含谷氨酸和γ-氨基丁酸的神经元的生化标志物存在异常。这些异常出现在腹侧额叶皮质和颞叶前部。有人认为，大脑的这些区域专门编码有关社交沟通——语言、手势和面部表情的信息。当精神分裂症的许多症状被视为社交沟通障碍时，从神经心理学角度就变得可以理解了。在本文及后续论文中，将描述对这一假设的实验测试。
