Taylor J M, Kim D K
Department of Biostatistics, University of California, Los Angeles 90024-1772.
Stat Med. 1994;13(19-20):2059-66. doi: 10.1002/sim.4780131915.
In this paper statistical methods are proposed to estimate the distribution of a CD4 T-cell number at the time of a clinical AIDS endpoint from serial measurements of CD4 T-cell values in a cohort study. The statistical formulation of the problem is that of survival analysis with interval censored data, but in which the endpoints are obtained with measurement error. A measurement error likelihood is developed, assuming normality of the CD4 distribution at AIDS. A maximum likelihood estimation procedure and a Gibbs sampling approach are implemented.
本文提出了统计方法，用于根据队列研究中CD4 T细胞值的系列测量结果，估计临床艾滋病终点时CD4 T细胞数量的分布。该问题的统计公式是带有区间删失数据的生存分析问题，但其中终点是通过测量误差获得的。在假设艾滋病时CD4分布呈正态性的情况下，建立了测量误差似然函数。实施了最大似然估计程序和吉布斯抽样方法。
