Derynck R
Department of Growth and Development, University of California at San Francisco 94143-0640.
Trends Biochem Sci. 1994 Dec;19(12):548-53. doi: 10.1016/0968-0004(94)90059-0.
Transforming growth factor beta (TGF-beta) and its many relatives are thought to play key roles in the control of cell proliferation and differentiation. In particular, the ability of TGF-beta to induce growth arrest in epithelial cells has drawn considerable attention. The recent cloning of TGF-beta receptors, which are considered to be prototypes of a new class of cell-surface receptors, has provided a first insight into how TGF-beta signaling induces a variety of intracellular changes. Furthermore, recent advances in the characterization of the cell-cycle machinery have stimulated studies aimed at understanding how TGF-beta signaling leads to growth arrest in the late G1 phase of the cell cycle.
转化生长因子β（TGF-β）及其众多相关因子被认为在细胞增殖和分化的调控中发挥关键作用。特别是，TGF-β诱导上皮细胞生长停滞的能力已引起了相当大的关注。TGF-β受体的近期克隆被认为是一类新型细胞表面受体的原型，这为深入了解TGF-β信号传导如何引发多种细胞内变化提供了初步认识。此外，细胞周期机制特征研究的最新进展激发了旨在理解TGF-β信号传导如何导致细胞周期G1期晚期生长停滞的研究。
